Obtaining a diagnosis for histamine intolerance can be challenging.  Histamine intolerance is an emerging area of medical science.

A physician’s may or may not be aware of histamine intolerance depending on his or her specialists interests and clinical experience.

Furthermore, the diagnosis of mast cell activation, is controversial.

One of the easiest ways to overcome this knowledge gap is to provide the clinician with the relevant research paper and ask them if you could be tested for histamine intolerance.

If your clinician is unable to consider these issues, then ask to be referred to a specialist, with a research interest in the area of food intolerances.

The articles which represent current knowledge are:

Histamine Intolerance

The most recent histamine intolerance guidelines were released in February 2017.

Diagnose Histamine Intolerance

DAO Deficiency

A recent study found that DAO deficiency accounts for 70% of all histamine intolerance:


(Histamine Intolerance)


(Histamine Intolerance Diagnosis)

NNMT Deficiency, and Mast cell Disorders

HNMT deficiency is considered an indicative marker of mast-cell disorders. Further testing however is required to diagnose a mast cell disorder.

The proposed diagnostic criteria for mast cell disorders are:


(Mast Cell Activation Syndrome Diagnosis)


(Mast Cell Disease)

Whilst the literature focuses on foods or medicine, as the primary way to management of symptoms, the functional health of the individual is arguably the greatest influence on histamine tolerance.

If you need help figuring this out I am now working jointly with a leading naturopath, and a functional doctor, to provide evidenced based solutions. If you want to find out more about the Living Health Clinic, you can schedule a FREE appointment to find out about working with us.