MTHFR? Vitamin C Can Boost Your Folate by 50%
Do you have mutations of MTHFR? Vitamin C can boost your folate by 50%.
Folate is a critical nutrient for protecting DNA and in homocysteine methylation. Yet folate is very fickle.
If you have an MTHFR mutation, in the presence of oxidative stress, then folate can become unstable and wreak havoc.
However, at least three small human studies, have shown that vitamin C acts to stabilise folate. Not only that but it helps to absorb it even with a fickle C667T MTHFR polymorphism.
Here are the findings:
- Dosages were 5-methyltetrahydrofolate (343mcg) with ascorbic acid (either 289.4mg or 973.8mg).
- Folate levels increased by 36% and 56% (that is in a dose dependent manner).
- Vitamin C protected folate in the gastro-intestinal tract, intracellularly, the nervous system, and brain.
- Results were maintained even with a C667T variant of MTHFR.
These studies suggest that vitamin C levels (rather than simply the rouge MTHFR gene) are the key protective factor.
For those of you with histamine intolerance vitamin C increases diamine oxidase making it doubly important. The recommended dosage for histamine intolerance is around 2000 mcg a day which is more than double that used in the folate studies.
Lucock M, Yates Z, Boyd L, Naylor C, Choi JH, Ng X, Skinner V, Wai R, Kho J, Tang S, Roach P, Veysey M. Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status. Eur J Nutr. 2013 Mar;52(2):569-82. doi: 10.1007/s00394-012-0359-8. Epub 2012 Apr 21. PubMed PMID: 22527288.
Verlinde PH, Oey I, Hendrickx ME, Van Loey AM, Temme EH. L-ascorbic acid improves the serum folate response to an oral dose of [6S]-5-methyltetrahydrofolic acid in healthy men. Eur J Clin Nutr. 2008 Oct;62(10):1224-30. Epub 2007 Jul 11. PubMed PMID: 17622258.
Aylett SB, Neergheen V, Hargreaves IP, Eaton S, Land JM, Rahman S, Heales SJ. Levels of 5-methyltetrahydrofolate and ascorbic acid in cerebrospinal fluid are correlated: implications for the accelerated degradation of folate by reactive oxygen species. Neurochem Int. 2013 Dec;63(8):750-5. doi: 10.1016/j.neuint.2013.10.002. Epub 2013 Oct 15. PubMed PMID: 24140430.