New Ingredient: Glutathione Setria

I wanted to update you on a new ingredient Glutathione Setria® that has hit the market which I am now personally taking.

There are three things going for this ingredient over the Seeking Health Liposomal Glutathione that I have been taking to date.


The product I have trialled is  Healthy Origins, Setria, L-Glutathione Reduced, 500 mg, 150 Capsules although the Setria® ingredient is widely available. It is a peptide based version of the three precursors to glutathione.


Its about half to a third the cost of the liposomal products. Enough said.


There is none because it is a powder in a veggie gel cap. No need to grin and bear that strong sulfur taste anymore.

Clinical Trials;

Clearly show that it raises glutathione by up to 1/3rd.  Yes they were done by the company itself, and yes there is only one clinical trial, but its one more than most products. Also from this human test tube’s perspective it works! I literally can feel it in my body when I take it and when I don’t.


The Setria® process is rather secretive because it is a trade secret. It appears to involve fermentation but does not result in a histamine reaction for me personally.

Independent View

I have no link to the developers of Setria®; other than I am converted.


Why Glutathione? 

I have written extensively on the importance of glutathione on my blog.

It is my experience that many folk with histamine intolerance or mast cell activation symptoms have had a toxic shock that was the trigger for the symptoms. In my case it was an adverse drug reaction linked to CYP450 mutations. Glutathione has been critical to my return to health.

Glutathione helps to;

– Neutralise toxins and chemicals to prevent cell damage.
– Regenerates other anti-oxidants, such as Vitamin C and E.
– Protect cell proteins.
– Supporting the immune system’s killer cells.
– Regulate methylation cycles; such that little progress can be made until glutathione is addressed.

Whilst a healthy body can typically create sufficient glutathione from a healthy diet it may also have a higher requirement. If you are wondering you can easily ask for your glutathione levels to be tested.

Glutathione is one of the most important protective molecules in the body. Its really that important.

Additional Reading

Glutathione: Reverse your Inflammation

What If This Was About The Liver?

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  • Shelley

    Of course, there is no gluten and no aluminum, right? Will they tell us that? Thank you!

  • Tanya Bee

    as always, thank you for all your work and information! I received my bottle in the mail today and am excited to start with it soon.

  • Philip Clax

    I tried the glutathione and felt very fatigued and brain fogged, is this a detox reaction? Or maybe I’m just sensitive to sulfur products.

  • ann

    Micro nutrient testing has shown my glutathione levels to be very low. When I tried supplementing with liposomal glutathione I got hives from head to toe. Do you think that this new form of glutathione might work for me?

    • I am not sure what is going on for you. Personally I would start with whole foods first in reasonable quantities. Also check the brand and other ingredients.

      • ann

        I have hyperoxaluria, glutamate and salicylate sensitivity and recently discovered histamine intolerance. I was working with a nutritionist who recommended all kinds of supplements. I had reactions to many of them. The l.glutathione, whey and rice protein caused the worst reactions. She kept saying how important glutathione is but could not figure out a way to increase it. The root cause of all this is still unknown. She suspected mercury. The MD I am currently seeing seems to think it is Lyme. I do eat sulphur veggies with no problem. maybe I will try to increase the amount. Thanks for your input.

        • Oh boy where to start. I would need more history (and this is not the place). The biggest issue I see within my practice is people not being tested for the basics but jumping to genetics. Lyme and SIBO are the two biggest issues I see when there are super extreme reactions to a wide range of foods. You should speak to your MD and ask him if it is appropriate to be tested for those based on your own medical history. The biggest lingering cause of MACD I see in my practice is HPA axis issues (adrenal and hormone) and their accompanying metal imbalances (hair mineral analysis). An HPA test; that shows cortisol x 4, DHEA, Testosterone, Estrogen, Melatonin will shows you what is misfiring IMO.

          • ann

            Thanks, I will look into the tests you mentioned.

          • Guest

            Wouldn’t the gut problems come first, followed by adrenal/HPA axis issues?

          • Not necessarily you can have adrenal problems without gut problems.

  • sallycinnamonau

    Hi Alison,
    Do you know if Setria should be taken on an empty stomach or with meals? Also what dosing is generally used? I’ve got 250mg capsules, thinking of split-dosing through the day.

    • there is no “standard dosage” as it depends upon what your glutathione status. It would be best to check with your health practitioner about your own situation. There is some generic information here;

  • moore2come

    Vitamin C raises intracellular glutathione 50%

  • Mia

    Hi Alison,

    I’ve read that glutathione is best absorbed topically and not internally, with the exception of the liposomal products which can also be taken internally. Do you feel that the Setria form survives the digestive process enough to be absorbed by the body? The liposomal products are expensive, and this seems so much more cost effective, as you said. The one study you mentioned seems promising, but I wonder if it’s worth trying.

    • It is best absorbed liposomally (especially for intra-cellular heavy metals) or via an IV. The research on this product shows that it is absorbed somewhat and I do use it in some instances for people on a limited budget.

      • Mia

        Thank you, Alison. I appreciate your reply. 🙂