This blog post addresses why olive oil (and a paleo diet) increases diamine oxidase (DAO) and helps reduce the symptoms of histamine intolerance.
The intestinal mucosa is a protective layer in the gut that contains a wide range of enzymes used in digestion and nutrient absorption. One of these enzymes is DAO.
DAO protects the body against an excessive buildup of histamines by degrading both ingested and bacterial histamine.
The amount of DAO synthesised can be reduced due to a genetic mutation (DAO deficiency) but it is nutrients which make it bio-available. This means that what we eat will determine whether available DAO is transported into the gut and bloodstream.
This is not speculation. A study examined each of the key nutrients and here is what they found:
Fungal infections, histamine intolerance, and mast cells have a crucial connection which is often overlooked as one source of histamine intolerance.
It is common to talk about mast cells as part of an allergic (even anaphylactic) reaction. But their role in allergic reactions is only a small part of the job of the mast cell. Another crucial role mast cells play is in identifying and treating pathogen; such as bacteria, viruses, parasites and fungi.
Want to know which anti-inflammatory herb goes with what low histamine food? This infographic is my reference guide based on years of experimentation and avid cookbook reading. Herbs are amongst the highest goods in anti-oxidants, and offer an array of flavours, making them the perfect seasoning on a low histamine diet. Read More
I have been wanting to write for some time on the CYP450 medication, inflammation, and histamine connection, as this information has been so important in my own pathway to recovery.
I have had histamine intolerance all my life, but developed mast cell activation disorder, when put onCYP450 mediated (and in particular CYP2D6 related medication).
Simplistically, I have CYP2D6 genetic mutation, which pushed my body into oxidative stress, that resulted in chronic inflammation markers (mine were c-reactive protein, and ceruloplasmin).
There are many paths to histamine intolerance and mast-cell activation disorder and my path is just one of them. Medication intolerances, however, are extremely common once firmly on that pathway.
There are a number of reasons why medication may be problematic with histamine intolerance, and I am only addressing one of them, which is the CYP450 medication, inflammation, and histamine connection