Recently Chris Kresser did a podcast on histamine intolerance in which he discussed histamine degrading probiotics. I have great respect for Chris whom I have personally consulted on all things histamine. Unfortunately, in my opinion, his information was out of date.
This recipe for Esme’s Old Fashioned Apple and Rhubarb Pudding is heavily adapted from Yotam Ottolenghi’s book “Plenty More.”
I have modified his recipe, but he is a source of inspiration, with his style of less is more cooking. He is not a vegeterian, just a man who loves his vegetables, and I have given his book to many a paleo eater.
The anti-depressant, brain fog, and histamine intolerance connection, is another poorly understood area.
Drug intolerances are extremely common with histamine intolerance yet there is still much that is not known. Does histamine intolerance result in drug intolerance, or do drug intolerances trigger histamine intolerance in some people? We simply do not know.
We do know that:
- Certain DAO genes are associated with drug intolerances.
- A number of drugs release histamines, and block histamine metabolising enzymes.
- Cytochrome P450 Prescription drugs (including anti-depressants), generate free radicals, that release of histamines by mast-cells.
Beyond that there is still much work to be done. In the absence of clinical trials, we are left with clinical observations of medical professionals, working on the cutting edge in clinical practice.
This post looks at the medical hypothesis of Professor David Healy, a psychiatrist, and psycho-pharmacologist, with an active interest in adverse drug reactions to psychotropic drugs. Here are some of his interesting clinical observations relevant to histamine intolerance:
A new study by Maintz and Novak et al concludes that the histamine intolerance and diamine oxidase connection alone does not explain histamine intolerance (HIT). Previously, genetic mutations in DAO, were hypothesised to be the sole cause.
HIT is the result of an imbalance between histamine and the capacity for histamine…Read More