Fungal infections, histamine intolerance, and mast cells have a crucial connection which is often overlooked as one source of histamine intolerance.
It is common to talk about mast cells as part of an allergic (even anaphylactic) reaction. But their role in allergic reactions is only a small part of the job of the mast cell. Another crucial role mast cells play is in identifying and treating pathogen; such as bacteria, viruses, parasites and fungi.
Want to know which anti-inflammatory herb goes with what low histamine food? This infographic is my reference guide based on years of experimentation and avid cookbook reading. Herbs are amongst the highest goods in anti-oxidants, and offer an array of flavours, making them the perfect seasoning on a low histamine diet. Read More
I have been wanting to write for some time on the CYP450 medication, inflammation, and histamine connection, as this information has been so important in my own pathway to recovery.
I have had histamine intolerance all my life, but developed mast cell activation disorder, when put onCYP450 mediated (and in particular CYP2D6 related medication).
Simplistically, I have CYP2D6 genetic mutation, which pushed my body into oxidative stress, that resulted in chronic inflammation markers (mine were c-reactive protein, and ceruloplasmin).
There are many paths to histamine intolerance and mast-cell activation disorder and my path is just one of them. Medication intolerances, however, are extremely common once firmly on that pathway.
There are a number of reasons why medication may be problematic with histamine intolerance, and I am only addressing one of them, which is the CYP450 medication, inflammation, and histamine connection
If you have histamine intolerance, mast-cell activation disorder, or any other inflammatory disorder, then here are 21 anti-histamine foods that fight inflammation and stabilise mast-cells naturally (and also a further 21 supplements to boost nutritional reserves):
1. Watercress (Nasturtium officinale)
Watercress is a cruciferous vegetable that has a peppery, tangy, taste like rocket. It is considered one of the most nutrient dense plants commonly available. A study showed that watercress inhibits 60% of all histamines released from mast cells.
Study: Goda, Hoshino K, Akiyama H, Ishikawa T, Abe Y, Nakamura T, Otsuka H, Takeda Y, Tanimura A, Toyoda M, “Constituents in watercress: inhibitors of histamine release from RBL-2H3 cells induced by antigen stimulation”, Biol Pharm Bull. 1999 Dec;22(12):1319-26.