I have been wanting to write for some time on the CYP450 medication, inflammation, and histamine connection, as this information has been so important in my own pathway to recovery.
I have had histamine intolerance all my life, but developed mast cell activation disorder, when put onCYP450 mediated (and in particular CYP2D6 related medication).
Simplistically, I have CYP2D6 genetic mutation, which pushed my body into oxidative stress, that resulted in chronic inflammation markers (mine were c-reactive protein, and ceruloplasmin).
There are many paths to histamine intolerance and mast-cell activation disorder and my path is just one of them. Medication intolerances, however, are extremely common once firmly on that pathway.
There are a number of reasons why medication may be problematic with histamine intolerance, and I am only addressing one of them, which is the CYP450 medication, inflammation, and histamine connection
If you have histamine intolerance, mast-cell activation disorder, or any other inflammatory disorder, then here are 21 anti-histamine foods that fight inflammation and stabilise mast-cells naturally (and also a further 21 supplements to boost nutritional reserves):
1. Watercress (Nasturtium officinale)
Watercress is a cruciferous vegetable that has a peppery, tangy, taste like rocket. It is considered one of the most nutrient dense plants commonly available. A study showed that watercress inhibits 60% of all histamines released from mast cells.
Study: Goda, Hoshino K, Akiyama H, Ishikawa T, Abe Y, Nakamura T, Otsuka H, Takeda Y, Tanimura A, Toyoda M, “Constituents in watercress: inhibitors of histamine release from RBL-2H3 cells induced by antigen stimulation”, Biol Pharm Bull. 1999 Dec;22(12):1319-26.
This paleo low histamine porridge is delicious. Not only that but it is jam-packed with anti-inflammatory nutrition.
I have a mild obsession with chia-seeds. They give you all the creaminess of cream caramel without the guilt.
If you have not used these amazing seeds before then I encourage you to try them. What starts as a tiny seed, once activated, becomes a sponge. Can you believe this huge bowl of porridge was made from just 4 tablespoons of seeds?
In a recent podcast on cardio-vascular disease, Chris Kresser discussed natural aspirin alternatives (that are anti-histamines and mast-cell stabilisers). (1)
Chris concluded that research showed that natural aspirin alternatives were as effective as aspirin with none of the side-effects.
He identified both Pycnogenol® (pronounced Pik-nah-jeh-nol) and Policosanol to have been found to be as effective as aspirin for cardio-vascular health. (2) (3)
In this post I provide additional information on these natural aspirin alternatives (that are anti-histamines and mast-cell stabilisers).