The CYP450 Medication, Inflammation, and Histamine Connection

The CYP450 Medication, Inflammation, and Histamine Connection

I have been wanting to write for some time on the CYP450 medication, inflammation, and histamine connection, as this information has been so important in my own pathway to recovery.

My story

I have had histamine intolerance all my life, but developed mast cell activation disorder, when put onCYP450 mediated (and in particular CYP2D6 related medication).

Simplistically, I have CYP2D6 genetic mutation, which pushed my body into oxidative stress, that resulted in chronic inflammation markers (mine were c-reactive protein, and ceruloplasmin).

There are many paths to histamine intolerance and mast-cell activation disorder and my path is just one of them. Medication intolerances, however, are extremely common once firmly on that pathway.

There are a number of reasons why medication may be problematic with histamine intolerance, and I am only addressing one of them, which is the CYP450 medication, inflammation, and histamine connection

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21 Anti-histamine Foods That Fight Inflammation And Stabilise Mast-Cells

September 23, 2014  |  Blog, Histamine Intolerance  |  86 Comments

If you have histamine intolerance, mast-cell activation disorder, or any other inflammatory disorder, then here are 21 anti-histamine foods that fight inflammation and stabilise mast-cells naturally (and also a further 21 supplements to boost nutritional reserves):

VEGETABLES

anti histamine watercress

1. Watercress (Nasturtium officinale)

Watercress is a cruciferous vegetable that has a peppery, tangy, taste like rocket. It is considered one of the most nutrient dense plants commonly available. A study showed that watercress inhibits 60% of all histamines released from mast cells.

Study: Goda, Hoshino K, Akiyama H, Ishikawa T, Abe Y, Nakamura T, Otsuka H, Takeda Y, Tanimura A, Toyoda M, “Constituents in watercress: inhibitors of histamine release from RBL-2H3 cells induced by antigen stimulation”, Biol Pharm Bull. 1999 Dec;22(12):1319-26.

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Paleo Low Histamine Porridge

Paleo Low Histamine Porridge

This paleo low histamine porridge is delicious. Not only that but it is jam-packed with anti-inflammatory nutrition.

I have a mild obsession with chia-seeds. They give you all the creaminess of cream caramel without the guilt.

If you have not used these amazing seeds before then I encourage you to try them. What starts as a tiny seed, once activated, becomes a sponge. Can you believe this huge bowl of porridge was made from just 4 tablespoons of seeds?

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Natural Aspirin Alternatives (That Are Anti-Histamines and Mast-cell Stabilisers)

Natural Aspirin Alternatives (That Are Anti-Histamines and Mast-cell Stabilisers)

In a recent podcast on cardio-vascular disease, Chris Kresser discussed natural aspirin alternatives (that are anti-histamines and mast-cell stabilisers). (1)

Chris concluded that research showed that natural aspirin alternatives were as effective as aspirin with none of the side-effects.

He identified both Pycnogenol® (pronounced Pik-nah-jeh-nol) and Policosanol to have been found to be as effective as aspirin for cardio-vascular health. (2) (3)

In this post I provide additional information on these natural aspirin alternatives (that are anti-histamines and mast-cell stabilisers).

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