I have been wanting to write this post for some time about CYP450 inhibitors: a complete list of the most potent inhibiting and inducing foods and bio-actives for some time. This information has made one of the biggest difference to my health and wellbeing and continues to do so.
It has become abundantly clear to me that the trigger of my mast cell activation was CYP450 mutations and prescription medication. I am also not alone as around 10% of the population have a similar mutation.
This Chicken Chow Mein recipe is about as close to Chinese food now as it gets for me.
When I was growing up in Australia in the 70s, Chinese restaurants, were everywhere and exotic. Then I lived in Hong Kong and worked extensively throughout Asia in the 80s. Either way Asian Food has a lot of memories for me.
Unfortunately MSG is one of them. If I eat MSG these days, my eyes immediately puff up with cczema, and I get sick. Glutamates it turns out are processed by the same pathways at histamine, so it can also have a knock on effect to my histamine threshold.
So to continue my trip down memory lane, this is my modified version of the chemical laden version, from my childhood. It is another quick, easy, and nutritious meal and often a favourite with kids. It also appeals to my mish mash meal love.
Vitamin B6 is a cluster of compounds (not just one) that is a co-factor in over 100 biochemical reactions in the body which is why your Vitamin B6 level is important.
Here are just a few of the things that studies show that it does for you:
- Increases diamine oxidase plasma levels.
- Degrading glutamates and MSG.
- Metabolises proteins.
- Reduces oxalate levels
- Inhibits the degranulation of mast-cells.
- Moderates cortisol levels.
- Regulates blood sugar levels and glucose tolerance.
- Converts ALA to DHA.
- Acts as a potent anti-oxidant.
- Synthesises neurotransmitters; serotonin, dopamine, and GABA, and norepinephrine.
- Relieves PMS, dermatitis, mosquito bites, irritability, depression, and short-term memory issues.
The humble vitamin C increases diamine oxidase making it one of the simplest and cheapest treatments for histamine intolerance.
Here is a quick summary of current research findings:
- Dosage recommendations are between 1 – 3 grams a day, with 2 grams a general recommendation.
- Vitamin C increases diamine oxidase which then metabolises excess histamine.
- Vitamin C does not stop histamine degranulation from mast cells. It does not affect tryptase levels.
- Chewable tablets (absorbed orally) are the most rapidly absorbed (including by the brain) in an emergency.
- Vitamin C can also reduce nausea and sea-sickness.