Posts Tagged ‘diamine oxidase’
One of my current frustrations is that 23andMe™, and online report readers, are used to self-diagnose rather than get the lab test for histamine intolerance.
Here is a report from a popular online 23andMe™ report reader of the “DAO” snps from one of my clients.
You could be forgiven for thinking that…Read More
Do you have mutations of MTHFR? Vitamin C can boost your folate by 50%.
Folate is a critical nutrient for protecting DNA and in homocysteine methylation. Yet folate is very fickle.
If you have an MTHFR mutation, in the presence of oxidative stress, then folate can become unstable and wreak havoc.
However, at least three small human studies, have shown that vitamin C acts to stabilise folate. Not only that but it helps to absorb it even with a fickle C667T MTHFR polymorphism.
Vitamin B6 is a cluster of compounds (not just one) that is a co-factor in over 100 biochemical reactions in the body which is why your Vitamin B6 level is important.
Here are just a few of the things that studies show that it does for you:
- Increases diamine oxidase plasma levels.
- Degrading glutamates and MSG.
- Metabolises proteins.
- Reduces oxalate levels
- Inhibits the degranulation of mast-cells.
- Moderates cortisol levels.
- Regulates blood sugar levels and glucose tolerance.
- Converts ALA to DHA.
- Acts as a potent anti-oxidant.
- Synthesises neurotransmitters; serotonin, dopamine, and GABA, and norepinephrine.
- Relieves PMS, dermatitis, mosquito bites, irritability, depression, and short-term memory issues.
The humble vitamin C increases diamine oxidase making it one of the simplest and cheapest treatments for histamine intolerance.
Here is a quick summary of current research findings:
- Dosage recommendations are between 1 – 3 grams a day, with 2 grams a general recommendation.
- Vitamin C increases diamine oxidase which then metabolises excess histamine.
- Vitamin C does not stop histamine degranulation from mast cells. It does not affect tryptase levels.
- Chewable tablets (absorbed orally) are the most rapidly absorbed (including by the brain) in an emergency.
- Vitamin C can also reduce nausea and sea-sickness.