Posts Tagged ‘diamine oxidase’
Do you have mutations of MTHFR? Vitamin C can boost your folate by 50%.
Folate is a critical nutrient for protecting DNA and in homocysteine methylation. Yet folate is very fickle.
If you have an MTHFR mutation, in the presence of oxidative stress, then folate can become unstable and wreak havoc.
However, at least three small human studies, have shown that vitamin C acts to stabilise folate. Not only that but it helps to absorb it even with a fickle C667T MTHFR polymorphism.
Vitamin B6 is a cluster of compounds (not just one) that is a co-factor in over 100 biochemical reactions in the body which is why your Vitamin B6 level is important.
Here are just a few of the things that studies show that it does for you:
- Increases diamine oxidase plasma levels.
- Degrading glutamates and MSG.
- Metabolises proteins.
- Reduces oxalate levels
- Inhibits the degranulation of mast-cells.
- Moderates cortisol levels.
- Regulates blood sugar levels and glucose tolerance.
- Converts ALA to DHA.
- Acts as a potent anti-oxidant.
- Synthesises neurotransmitters; serotonin, dopamine, and GABA, and norepinephrine.
- Relieves PMS, dermatitis, mosquito bites, irritability, depression, and short-term memory issues.
The humble vitamin C increases diamine oxidase making it one of the simplest and cheapest treatments for histamine intolerance.
Here is a quick summary of current research findings:
- Dosage recommendations are between 1 – 3 grams a day, with 2 grams a general recommendation.
- Vitamin C increases diamine oxidase which then metabolises excess histamine.
- Vitamin C does not stop histamine degranulation from mast cells. It does not affect tryptase levels.
- Chewable tablets (absorbed orally) are the most rapidly absorbed (including by the brain) in an emergency.
- Vitamin C can also reduce nausea and sea-sickness.
A new study by Maintz and Novak et al concludes that the histamine intolerance and diamine oxidase connection alone does not explain histamine intolerance (HIT). Previously, genetic mutations in DAO, were hypothesised to be the sole cause.
Histamine Intolerance
HIT is the result of an imbalance between histamine and the capacity for histamine…
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