Posts Tagged ‘diamine oxidase’
Vitamin B6 is a cluster of compounds (not just one) that is a co-factor in over 100 biochemical reactions in the body which is why your Vitamin B6 level is important.
Here are just a few of the things that studies show that it does for you:
- Increases diamine oxidase plasma levels.
- Degrading glutamates and MSG.
- Metabolises proteins.
- Reduces oxalate levels
- Inhibits the degranulation of mast-cells.
- Moderates cortisol levels.
- Regulates blood sugar levels and glucose tolerance.
- Converts ALA to DHA.
- Acts as a potent anti-oxidant.
- Synthesises neurotransmitters; serotonin, dopamine, and GABA, and norepinephrine.
- Relieves PMS, dermatitis, mosquito bites, irritability, depression, and short-term memory issues.
The humble vitamin C increases diamine oxidase making it one of the simplest and cheapest treatments for histamine intolerance.
Here is a quick summary of current research findings:
- Dosage recommendations are between 1 – 3 grams a day, with 2 grams a general recommendation.
- Vitamin C increases diamine oxidase which then metabolises excess histamine.
- Vitamin C does not stop histamine degranulation from mast cells. It does not affect tryptase levels.
- Chewable tablets (absorbed orally) are the most rapidly absorbed (including by the brain) in an emergency.
- Vitamin C can also reduce nausea and sea-sickness.
A new study by Maintz and Novak et al concludes that the histamine intolerance and diamine oxidase connection alone does not explain histamine intolerance (HIT). Previously, genetic mutations in DAO, were hypothesised to be the sole cause.
HIT is the result of an imbalance between histamine and the capacity for histamine…Read More
This blog post addresses why olive oil (and a paleo diet) increases diamine oxidase (DAO) and helps reduce the symptoms of histamine intolerance.
The intestinal mucosa is a protective layer in the gut that contains a wide range of enzymes used in digestion and nutrient absorption. One of these enzymes is DAO.
DAO protects the body against an excessive buildup of histamines by degrading both ingested and bacterial histamine.
The amount of DAO synthesised can be reduced due to a genetic mutation (DAO deficiency) but it is nutrients which make it bio-available. This means that what we eat will determine whether available DAO is transported into the gut and bloodstream.
This is not speculation. A study examined each of the key nutrients and here is what they found: