Posts Tagged ‘glutathione’
This little breakfast dish is so brimming with glutathione rich nutrition.
Asparagus, watercress, capers, and duck eggs, have two things in common. They are each individually extremely high in glutathione and they are a marriage made in heaven.
Eggs (and particularly egg whites) are often problematic, on a low histamine diet. I do tolerate duck eggs so I eat them.
I have been wanting to write for some time on the CYP450 medication, inflammation, and histamine connection, as this information has been so important in my own pathway to recovery.
I have had histamine intolerance all my life, but developed mast cell activation disorder, when put onCYP450 mediated (and in particular CYP2D6 related medication).
Simplistically, I have CYP2D6 genetic mutation, which pushed my body into oxidative stress, that resulted in chronic inflammation markers (mine were c-reactive protein, and ceruloplasmin).
There are many paths to histamine intolerance and mast-cell activation disorder and my path is just one of them. Medication intolerances, however, are extremely common once firmly on that pathway.
There are a number of reasons why medication may be problematic with histamine intolerance, and I am only addressing one of them, which is the CYP450 medication, inflammation, and histamine connection
In a recent podcast on cardio-vascular disease, Chris Kresser discussed natural aspirin alternatives (that are anti-histamines and mast-cell stabilisers). (1)
Chris concluded that research showed that natural aspirin alternatives were as effective as aspirin with none of the side-effects.
He identified both Pycnogenol® (pronounced Pik-nah-jeh-nol) and Policosanol to have been found to be as effective as aspirin for cardio-vascular health. (2) (3)
In this post I provide additional information on these natural aspirin alternatives (that are anti-histamines and mast-cell stabilisers).
I have had histamine intolerance (and specifically DAO deficiency) all my life. Until my 40s it was just inconvenient. Then it became chronic.
My auto-immune system became “hysterical.” I started having reactions to more and more foods, and then a banquet of environmental toxins, that glutathione plays a crucial role in detoxifying.
I was intolerant to vitamin c, and to quercetin, which acted as pro-oxidants (rather than as anti-oxidants), at even tiny levels in my toxic body. It turns out that glutathione is a master anti-oxidant that regulates these anti-oxidants.
I was also intolerant to all methylation donors. Methylation involves four interlocking, conversion processes; folate, methylation, B12, and glutathione that are important to detoxification.
According to Dr Ben Lynch, the glutathione cycle is the most important of these cycles. Until glutathione depletion is addressed all other methylation interventions are futile.
Also I had chronic acute inflammation markers which were “off the charts” including ceruloplasmin (which regulates copper), c-reactive protein, and metabolic markers. I put on 30 kilos in about 6 weeks in response to inflammation.
It turns out, a glutathione deficiency, was driving my chronic symptoms.