Posts Tagged ‘mast cell stabiliser’
I have been wanting to write this post for some time about CYP450 inhibitors: a complete list of the most potent inhibiting and inducing foods and bio-actives for some time. This information has made one of the biggest difference to my health and wellbeing and continues to do so.
It has become abundantly clear to me that the trigger of my mast cell activation was CYP450 mutations and prescription medication. I am also not alone as around 10% of the population have a similar mutation.
Vitamin B6 is a cluster of compounds (not just one) that is a co-factor in over 100 biochemical reactions in the body which is why your Vitamin B6 level is important.
Here are just a few of the things that studies show that it does for you:
- Increases diamine oxidase plasma levels.
- Degrading glutamates and MSG.
- Metabolises proteins.
- Reduces oxalate levels
- Inhibits the degranulation of mast-cells.
- Moderates cortisol levels.
- Regulates blood sugar levels and glucose tolerance.
- Converts ALA to DHA.
- Acts as a potent anti-oxidant.
- Synthesises neurotransmitters; serotonin, dopamine, and GABA, and norepinephrine.
- Relieves PMS, dermatitis, mosquito bites, irritability, depression, and short-term memory issues.
Recently Chris Kresser did a podcast on histamine intolerance in which he discussed histamine degrading probiotics. I have great respect for Chris whom I have personally consulted on all things histamine. Unfortunately, in my opinion, his information was out of date.
I have been wanting to write for some time on the CYP450 medication, inflammation, and histamine connection, as this information has been so important in my own pathway to recovery.
My story
I have had histamine intolerance all my life, but developed mast cell activation disorder, when put onCYP450 mediated (and in particular CYP2D6 related medication).
Simplistically, I have CYP2D6 genetic mutation, which pushed my body into oxidative stress, that resulted in chronic inflammation markers (mine were c-reactive protein, and ceruloplasmin).
There are many paths to histamine intolerance and mast-cell activation disorder and my path is just one of them. Medication intolerances, however, are extremely common once firmly on that pathway.
There are a number of reasons why medication may be problematic with histamine intolerance, and I am only addressing one of them, which is the CYP450 medication, inflammation, and histamine connection
