Posts Tagged ‘oxidative stress and inflammation’
Histamine intolerance is often misperceived as a diagnosis with a one-dimensional solution aimed at lowering dietary histamines.
I believe that this one-dimensional focus is misconceived. At best this leaves someone who is histamine intolerant managing symptoms. At worst it leaves them ignoring he main source of histamine intolerance.
I believe that histamine intolerance…Read More
This post on glutathione: a list of the most potent inhibiting and inducing anti-oxidant foods and bioactives, is a companion to CYP450 Enzymes: A Complete List of the Most Potent Inhibiting and Inducing Foods and Bioactives.
Those of you who are regular readers of my blog will know that glutathione is to me what turmeric or quercetin is to others. I can literally feel a dramatic difference in my health and wellbeing.
Whilst it has become abundantly clear to me that the trigger of my mast cell activation was CYP450 mutations (a Phase 1 Liver issue) and prescription medication (which resulted in a toxic shock due to the CYP450 mutation), it is also abundantly clear to me that my body laps up glutathione and anti-oxidants.
Why? Because glutathione and anti-oxidants are critical to detoxification.
I have been wanting to write this post for some time about CYP450 inhibitors: a complete list of the most potent inhibiting and inducing foods and bio-actives for some time. This information has made one of the biggest difference to my health and wellbeing and continues to do so.
It has become abundantly clear to me that the trigger of my mast cell activation was CYP450 mutations and prescription medication. I am also not alone as around 10% of the population have a similar mutation.
I have had histamine intolerance (and specifically DAO deficiency) all my life. Until my 40s it was just inconvenient. Then it became chronic.
My auto-immune system became “hysterical.” I started having reactions to more and more foods, and then a banquet of environmental toxins, that glutathione plays a crucial role in detoxifying.
I was intolerant to vitamin c, and to quercetin, which acted as pro-oxidants (rather than as anti-oxidants), at even tiny levels in my toxic body. It turns out that glutathione is a master anti-oxidant that regulates these anti-oxidants.
I was also intolerant to all methylation donors. Methylation involves four interlocking, conversion processes; folate, methylation, B12, and glutathione that are important to detoxification.
According to Dr Ben Lynch, the glutathione cycle is the most important of these cycles. Until glutathione depletion is addressed all other methylation interventions are futile.
Also I had chronic acute inflammation markers which were “off the charts” including ceruloplasmin (which regulates copper), c-reactive protein, and metabolic markers. I put on 30 kilos in about 6 weeks in response to inflammation.
It turns out, a glutathione deficiency, was driving my chronic symptoms.