Zeolite Binds Histamines
Over the last year or so, I have been using zeolite rather than prescription medication, to successfully detoxify mold, only to find that in addition to mold, zeolite binds histamines providing another way to neutralize excess histamines in the gastrointestinal tract.
Zeolite is a natural clay-like substance, that has a honeycomb-like structure, that absorbs into its pores, selective ingredients including excess histamine.
The human body is designed to process or deactivate histamines by using diamine oxidase enzymes to alter histamines so they cannot be reabsorbed in the intestinal mucosa.
Diamine oxidase (DAO) enzymes in the intestinal tracts chemically alter histamines or deactivate them so they cannot be reabsorbed and circulate throughout the body.
However, that process is limited. When there is too little diamine oxidase being made, or too many histamines circulating, the body cannot keep up with demand.
However, Zeolite jumps over that limitation. It simply binds up histamine in the gastrointestinal tract, hides histamine away from the body in its porous cavities, and directly eliminates it via the stool. It bypasses the DAO, HNMT, and MAO regulatory systems altogether.
As it works on the gastrointestinal tracts it does not address histamine in the blood which is a marker of methylation issues.
Here are just a few of the ways that zeolite has been found to help histamine degradation.
High Histamine Foods
Digested histamines are strongly bound to zeolite when zeolite powder is consumed within 30 minutes of food. Indeed, studies show that up to 82% of ingested histamines are bound.
A small human study has demonstrated that zeolite significantly reduces the effects of alcohol consumption (but not blood alcohol levels).
A small animal study found zeolite was protective of diamine oxidase levels and intestinal barrier function.
A substantial human study of zeolite supplementation found a 30% improvement in zonulin (a marker of intestinal integrity). There was no significant change in the status of key nutrients.
A 2017 animal study, also found that zeolite resulted in significant improvements in the gut villus (height, perimeter, section area) in the gut mucosa.
There is evidence that zeolite reinforces or coats the mucosal barrier to protect it from the toxic effects of drugs and toxins.
The same 2017 animal study, found that there was a significant increase in digestive enzymes and nutrient absorption.
Inflammatory Bowel Disease
Leaky gut is thought to be a crucial step in the development of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.
A 2018 animal study, found that zeolite reduced gut inflammation and that an inflamed gut can be exposed to zeolite for a prolonged period without it being absorbed into the cells.
The outer cell wall of gram-negative bacteria contains pro-inflammatory lipopolysaccharides which are known to activate mast-cells.
In an animal study, zeolite acted as an anti-inflammatory, preventing lipopolysaccharides from stimulating a variety of inflammatory markers, and regulating the immune system.
This improvement may be due to the lowering of chronic infections (see below) or improvement in the intestinal mucosa.
Other Health Benefits of Zeolite
- Heavy metals (other binders can be more selective),
- Free radicals,
- Some pathogenic bacteria, Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Salmonella,
- Fungal toxins,
- Bile acids, and
Zeolite is a smart detoxifier as it does not absorb essential minerals (such a zinc, calcium, or magnesium) and amino acids, rather it absorbs selective ingredients including histamine. It is same for long-term use.
How To Use Zeolite
There are many types of zeolite in nature. Not all forms of zeolite work in the same way, because of their size, chemical structure, or purity.
The products that I have used are Lava Vitae Zeolite, Zeolith MED, and Biopure Zeo Bind (which Dr. Klinghardt recommends including for mold detoxification).
These brands have products available in powder (generally more economical – and can address histamines in the small intestine as well) and capsules which pass through the small intestine.
When using the powder, it is important to use a wooden or plastic spoon to stir the zeolite, as a metal one can change its charge, making it less effective at pulling out toxins.
Needless to say, it is also important to ensure that any constipation is resolved or managed. Having bound up the histamine, it needs to be excreted, otherwise, it will be reabsorbed.
Zeolite has become a part of my core protocol, is a core part of Dr. Klinghardt’s protocol, and I am including it more and more in client protocols.
Not only has it a lot of clinical experience in detoxifying histamines but it also has a mounting body of research. It is well tolerated and is virtually tasteless.
Whats more it seems such a simple, almost genius, solution to histamine problems.
Please consult your physician before trialing this product. I am providing this information based on my own exceptional personal experiences and in order for you to open a conversation with your own healthcare provider.
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Kuley, Esmeray, et al. “The impact of applying natural clinoptilolite (zeolite) on the chemical, sensory and microbiological changes of vacuum packed sardine fillets.” International journal of food science & technology 47.9 (2012): 1977-1985.
Wu, Qiu Jue, et al. “The effects of natural and modified clinoptilolite on intestinal barrier function and immune response to LPS in broiler chickens.” Veterinary immunology and immunopathology 153.1 (2013): 70-76.
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